What are the factors that determine IVF success rate?

 There are two major treatments or Assisted reproductive technologies used nowadays at the top fertility clinics. First, IVF (or In Vitro Fertilization) is a process whereby an egg and sperm are combined outside, and the procured embryo is transferred back to the uterus. Second, IUI is a process in which the sperm is placed inside the uterus to reach the fallopian tubes. The success rate of IUI also depends upon a few factors, just like the success of an IVF procedure.

However, you should understand that there is no guarantee of conceiving with the IVF process, even if the embryo and the uterus are in good shape. But with, the latest techniques incorporated by the top fertility clinics have considerably increased the success rate of IVF by improving the qualitative approach.

There are multiple factors that affect this success rate; let’s discuss them.

Primary Factors Affecting Success Rate in IVF Pregnancy

Age: With age, the success rate goes down in women as both ovarian reserve and egg quality decrease. Egg quality largely depends upon the patient’s lifestyle and nutritional diet habits. IVF can be more successful if done at the right age. Women between the age of 24-34 years are likely to get a successful IVF treatment due to higher fertility rates. By the age of 40, the success rate diminishes.

Male factors: Male factors affect success rates, such as teratozoospermia and DNA fragmentation. The quality of the oocytes and sperm cells also matters. A male partner’s fertility issues can affect the process and its success rate.

Past History: The history of previous pregnancy decides the success of IVF. If there has been a successful pregnancy before, there are better chances for the process to be successful. But if there is a history of fertility issues and miscarriages, then IVF might not be fruitful.

Stress: Stress level is an important determinant affecting the success rate to a greater extent. Similarly, uterine lining thickness, the outline of the uterine cavity, and immunological factors affect the success rate.

Facilities and Expertise Associated with the Process: Around 50-60% success of an IVF is dependent on embryo quality, which is dependent upon the availability of advanced techniques, experienced embryologists, and efficient clinical staff. A highly efficient embryologist and gynecologist can bring more successful results. Incubators play an important role in stabilizing the environment to regulate variables like O2 and CO2 gas concentrations, temperature, air particulates, and humidity levels.

Embryo Transfer: The most crucial step responsible for the success of IVF is the process where the embryo gets attached to the endometrial surface of the uterus, invades the epithelium, and maternal circulation forms the placenta.

Today, the top IVF clinics are offering considerably high IVF success rate in India because of the advanced techniques like optimized ovarian stimulation, closed working chamber, blastocyst culture, laser-assisted hatching, donor oocyte, hysteroscopy, PRP therapy, PGD/PGS, and endometrial receptivity test. Moreover, these modern and cutting-edge facilities and procedures assist in improving the IUI success rate as well.